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pentobarbital will increase toxicity of ifosfamide by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep track of. CYP3A4 inducers may possibly improve the metabolism of ifosfamide to its Energetic alkylating metabolites.pentobarbital will lower the extent or effect of atogepant by impacting hepatic/intestinal enzyme CYP3A4 met